Thursday, August 27, 2020

Einstein :: essays research papers

Albert Einstein, a well known researcher. Everybody realizes that. In any case, what amount do you truly think about him. All things considered, this article is to      Albert Einstein was conceived on March 15, 1879, in the town of Ulm, in Southern Germany. That town was situated at the foot of the Swabian Alps. His location was 135 Bahnhofstrasse yet that house was later crushed in a World War II shelling run. His folks were Hermann and Pauline Koch Einstein. Them two were Jewish, however didn’t emphatically practice the religion. Subsequently, â€Å"Israelitic† was composed on the Religion area of Einstein’s birth declaration. Two years after Einstein’s birth, Einstein’s sister, Maria, was conceived. Einstein could talk in entire sentences at three years old. Einstein’s mother, Pauline Einstein, adored music so Einstein took Violin exercises from age six to thirteen. Einstein’s father wasn’t a fruitful businessperson. He at that point began a pipes/electrical building organization with his sibling in Munich, trusting that would be a triumph. Albert went through the following 1 4 years of his life there. Albert should go to a Jewish school, yet his folks felt that he would show signs of improvement training at a Catholic School. He abhorred the school’s military convention and air. Einstein wasn’t exceptionally wise during this time. At twelve years old, he went to an exercise room, Luitpold Gymnasium to be progressively accurate, which resembles a center school and a secondary school consolidated. During at that point, he was beginning to peruse books on science. He met a poor researcher who helped Einstein in his examinations. The scholar’s name was Max Talmud. To support Einstein’s information, he gave Einstein a few difficult issues. One of them was to demonstrate the Pythagorean hypothesis. (See Diagram 1.) In 1894, Einstein’s family moved to Milan, Italy, however Einstein needed to remain in Munich to complete his examinations. Prior to the furthest limit of the school year, which was a half year after his folks left, he was advised to leave the recreation center on account of his lack of respect to his instructors. He at that point moved to Italy, which was an amazement to his folks since they weren’t anticipating him in Italy. At the point when he was 16â ½, he stepped through an exam to get into the Eidgenossische Technische Hochschule (ETH). You didn’t need a secondary school certificate to get into the ETH. Rather, you have to breeze through an extremely hard assessment. The ETH likewise assumed another significant job in Einstein’s life: it conceded ladies. Einstein :: papers research papers Albert Einstein, a well known researcher. Everybody realizes that. Be that as it may, what amount do you truly think about him. All things considered, this article is to      Albert Einstein was conceived on March 15, 1879, in the town of Ulm, in Southern Germany. That town was situated at the foot of the Swabian Alps. His location was 135 Bahnhofstrasse however that house was later pulverized in a World War II shelling run. His folks were Hermann and Pauline Koch Einstein. Them two were Jewish, however didn’t firmly practice the religion. In this way, â€Å"Israelitic† was composed on the Religion segment of Einstein’s birth authentication. Two years after Einstein’s birth, Einstein’s sister, Maria, was conceived. Einstein could talk in entire sentences at three years old. Einstein’s mother, Pauline Einstein, adored music so Einstein took Violin exercises from age six to thirteen. Einstein’s father wasn’t a fruitful agent. He at that point began a pipes/electrical designing organization with his sibling in Munich, trusting that would be a triumph. Albert went through the following 14 years of his life there. Albert should go to a Jewish school, yet his folks imagined that he would show signs of improvement training at a Catholic School. He detested the school’s military custom and air. Einstein wasn’t insightful during this time. At twelve years old, he went to a gym, Luitpold Gymnasium to be progressively definite, which resembles a center school and a secondary school consolidated. During at that point, he was beginning to peruse books on science. He met a poor researcher who helped Einstein in his examinations. The scholar’s name was Max Talmud. To help Einstein’s information, he gave Einstein a few difficult issues. One of them was to demonstrate the Pythagorean hypothesis. (See Diagram 1.) In 1894, Einstein’s family moved to Milan, Italy, yet Einstein needed to remain in Munich to complete his investigations. Prior to the furthest limit of the school year, which was a half year after his folks left, he was advised to leave the exercise center as a result of his lack of regard to his educators. He at that point moved to Italy, which was an amazement to his folks since they weren’t anticipating him in Italy. At the point when he was 16â ½, he stepped through an exam to get into the Eidgenossische Technische Hochschule (ETH). You didn’t need a secondary school confirmation to get into the ETH. Rather, you have to breeze through an exceptionally hard assessment. The ETH likewise assumed another significant job in Einstein’s life: it conceded ladies.

Saturday, August 22, 2020

Descartes Essay Example | Topics and Well Written Essays - 750 words

Descartes - Essay Example nd republished in 1642, â€Å"Meditations of First Philosophy,† which covers various philosophical themes that he was intensely put resources into talked about a portion of these points. One of these subjects incorporates the presence of God and whether something like this might exist. Anyway Descartes lived in a period where the Catholic Church held a lot of intensity. Had Descartes reached some other resolution than an agreed affirmation of God he may have been banned from the Church or, more awful, marked an apostate. So this makes one wonder did Descartes have faith in God or would he say he was cushioning his decisions to stay away from Church mistreatment? Descartes stated, â€Å"†¦were it not the case that God truly existed. By ‘God’ I mean the very being whom is inside me, that is, the owner of the considerable number of consummations which I can't grasp†¦Ã¢â‚¬  (Descartes 1-132). Descartes puts forth his defense in the â€Å"Meditations† that there must be a God. It resembles a geometric shape, steady, ever present, and resolute. He bolstered his decisions, basically, in view of the accompanying reasons (Kurtin). Basically this turns out to be as God is great however man isn't, which implies that God must exist on the grounds that a blemished being would not be equipped for thinking about an ideal one. In reasonableness, there are various imperfections in Descartes thinking on this point. He makes a supposition that since mankind is imperfect then God must be great. Since God is immaculate at that point man would never have created an ideal being. Be that as it may, none of these lines of reasoning ever offer substantial confirmation of the presence of God. In the event that works from the point of view, a one-sided one, since individuals needed to have confidence in God. It appears to be likely that that Descartes was the same. Be that as it may, as a savant he was unable to think about the truth without reflection and thought. He needed God to be genuine so he made a rationale that permits God to be genuine. This kind of reasoning serves the scholar quite well, yet may not be gotten also by

Friday, August 21, 2020

Blog Archive University of Virginia (Darden) Essay Analysis, 20192020

Blog Archive University of Virginia (Darden) Essay Analysis, 2019â€"2020 After completely reworking its MBA application essay questions last season, the admissions committee at the University of Virginia’s Darden School has done just a little fine-tuning this year. Candidates must still respond to five prompts and do so within a 700-word limit, but a new query has been added, while two previous ones have been combined into a single question. As a whole, the prompts again cover applicants’ personal, educational, and career objectives while touching on aspects of Darden’s particular character and ethosâ€"notably, its learning teams, vast international reach, and (now) diversity. In this analysis, we offer our best essay advice for all of the school’s 2019â€"2020 questions. Interested in learning how to tackle this year’s UVA Darden application essays? Watch the short video below before you continue reading the full analysis! Leadership: Darden strives to identify and cultivate responsible leaders who follow their purpose. Please provide an example of a situation in which you have made a meaningful impact. (200 words) Darden’s first essay prompt is an interesting hybrid of two questions it posed last season, one about leadership style and the other about impact. This new presentation cleverly touches on both, the assumption likely being that when you brought about the meaningful result in question, you did so while in a leadership position or at least when acting in a leadership capacity. Therefore, by describing what you achieved and how you did so, you will naturally also reveal information about your leadership style. At mbaMission, we love when admissions committees request examples, because they invite essays that use a narrative structure, and we believe such essays tend to be not only more revelatory but also more interesting to read (always good when trying to make an impression on someone who reads literally thousands of essays each year!). For example, you might start by launching directly into your story: “Although I had never led a committee that spanned three departments before, I found myself….” In a Darden FAQs blog post, an admissions representative advises, “Our basic advice is to show don’t tellâ€"examples are always best” but also cautions applicants to “not be so broad as to preclude self-reflection and meaningful insight. We are interested in getting to know how you think, how you approach working with others, your sense of self-awareness and your willingness to be self-reflective.” Because Darden wants to know about your “impact,” you will have to clearly show the results of your actions, but the admissions committee also wants to understand that the decisions you made and steps you took clearly paid off and that a project, company, organization, individual, or product experienced some kind of change as a result. In other words, in addition to explaining what was achieved and why it was significant, you must illustrate the values, thought process, and initiatives that made it possible. Also, make note of the words “responsible” and “purpose” in this prompt and keep them in mind as you brainstorm ideas for this mini essay. Qualities related to these concepts would be good ones to highlight if they are truly part of your authentic story. Diversity: Diversity and inclusion are critical to our mission and they work best when they are an integral and celebrated part of our community. Read University of Virginia’s Diversity Inclusion Vision Statement. Share a time in which you engaged with a perspective, identity, community, or experience that was different from your own and how it impacted your worldview. (200 words) In business schoolâ€"as in life in generalâ€"you will encounter people who think differently from you, operate according to different values, and react differently to the same stimuli. And success in an endeavor often involves considering and incorporating others’ input and standpoints. Via this essay, Darden hopes to learn how you view, approach, and react to such differences. Once enrolled in the school’s MBA program, you will be surrounded every day by people who are unlike you in a multitude of ways, and you will need to work in tandem with and alongside these individuals when analyzing case studies, completing group projects, and participating in other activities both inside and outside the classroom. The school is clearly seeking evidence that you are capable of listening, reflecting, learning, and growing and that you are open and receptive to things beyond your usual frame of reference. And by asking you to share a time when a novel “perspective, identity, community, or experience” changed you in some fundamental way, Darden is requesting actual evidence of this open-mindedness in action. To craft an effective essay response, consider using a narrative approach to describe a kind of “before and after” situation or “lightbulb moment” in which your takeaways from the experience influenced your subsequent thoughts, values, and/or actions. Perhaps you were exposed to something completely new that resonated with you and thereafter became a fundamental part of your mores or a routine practice in your life. Or maybe an experience challenged one of your existing beliefs and altered your opinion or stance in a significant way. Keep in mind, however, that the admissions committee is much more interested in your willingness and capacity to learn and grow than in the specific kind of change you experienced. Darden Worldwide â€" Travel: The Batten Foundation Worldwide Scholarship provides all Darden students in our full-time MBA program with an opportunity to participate in a Darden Worldwide Course. If you could choose any location in the world, where would you want to travel, and why? (50 words) First, we want to make sure you fully understand what this essay prompt is revealing. At our recent mbaMission annual conference, held this year on Darden grounds, Executive Director of Admissions and Financial Aid Dawna Clarke explained to us that because of this generous Batten scholarship, every single Darden student can now afford to participate in an international course at some point during their two years in the program. Business school is an experience rife with opportunities, and Darden wants to make sure no barriers stand in the way of its students taking advantage of this oneâ€"the chance to study abroad and explore new horizons. While this essay prompt had an air of the hypothetical last year, this year it is very much grounded in reality. So really plumb your interests and identify a location that truly excites youâ€"then write about it!   In just a few sentences, you can show your adventurous or intellectual side by pinpointing a country that sincerely appeals to you and reveals something interesting about you. But avoid writing a travelogue! Just clearly (and succinctly) explain why and how your choice will enhance both your education and others’. (Note that that paragraph is exactly 50 words long!) Learning Team: Tell us what you would want your learning team to know about you â€" personally, professionally, or both? (100 words) Before you start writing, we suggest you do some background work on what a learning team is and how it functions. At Darden, learning teams are carefully selected groups of five to six students, assembled with the intent of creating an eclectic mix of personalities and backgrounds. This group meets in the evenings, Sunday through Thursday, to tackle the next day’s case work together (and if you are not familiar with the case method, now is the time to do your homework on it as well!). Learning teams are a core element of the Darden experience, in part because some cases are so voluminous that students must take a divide-and-conquer approach and teach one another the material. In short, learning teams are intense and complex, requiring strong teamwork skills and contributions but capable of providing support and camaraderie as students work their way through Darden’s notoriously challenging first year. For your essay response to be successful and compelling, you will need to show that you have something to offer your future teammates. So, in a mere 100 words, you must reveal that you have a perspective, attribute, or background that will better enable your learning team to function. We are advocates of using anecdotes to reveal this kind of information and suggest you consider focusing on a single experience that demonstrates your positive team attributes and can represent how you would function on your learning team. This does not mean that you must describe a clichéd team experience to prove you are a team player. The key is simply to show you bring something of value to the table in this contextâ€"perhaps you are a great debater and can clearly see and elucidate multiple sides to a story, or you have particular experience with and insight into geopolitics, or you are naturally intellectually curious and have amassed a broad range of basic knowledge. Within reason, the trait does not matter! Establish that you have a skill or attribute that would be advantageous to Darden’s learning team experience, and you w ill send a compelling message.   To learn more about Darden’s learning teams and other characteristic elements of its MBA program, download a free copy of the mbaMission Insider’s Guide to the University of Virginia’s Darden School of Business Administration. What is your short-term, post-MBA career goal and why? (150 words) At our aforementioned annual conference, Dawna shared with us that one of her favorite expressions is “You don’t know what you don’t know” and that she keeps this maxim in mind when considering Darden applicants’ career goals. MBA students encounter an incredible (and often surprising) number and breadth of professional opportunities while in business school, and given her extensive admissions background, she knows only too well that candidates can and do change their minds and trajectories along the way. That said, Darden wants to know that you have given this aspect of your MBA experience very serious thought, have thoroughly researched your options, and are approaching business school with a strong sense of purposeâ€"that you have a fitting and attainable goal in mind and can articulate it clearly. Note that the admissions committee is asking only about your short-term goal, which is often a pretty practical one, compared with applicants’ typically more idealistic long-term goals. So, first make sure that the path you have chosen is a sensible one for you. Ask yourself, “Will a Darden MBA help me get from where I am now to where I want to be?” If, for example, you are a journalist and have dreams of working at a hedge fund after you graduate, the admissions committee will probably not respond very positively to your plan, because hedge funds tend to be the domain of math PhDs and seasoned finance professionals. The school wants to feel that you will be able to achieve your aspirations after completing its program, so you want to avoid goals that could sound farfetched. Instead, as a journalist, you would need to identify a far more realistic path, but one that is true to who you are. Being ambitious is great, but the goal you present must be connected to reality, and to d emonstrate that connection, you will have to spell out why your objective is a reasonable one for you. Establishing briefly that you have the skills and knowledge to enter your target field will make that logical connection for your admissions reader, reassuring them that you can be a happy and productive graduate. One’s short-term goal is a common topic in a traditional personal statement, so we encourage you to download your  free  copy of the  mbaMission Personal Statement Guide, which helps applicants write this style of essay for any school. This complimentary guide offers detailed advice on approaching and framing these subjects, along with multiple illustrative examples. Be sure to  claim your copy today. The Next Stepâ€"Mastering Your UVA Darden Interview:  Many MBA candidates find admissions interviews stressful and intimidating, but mastering this important element of the application process is definitely possibleâ€"the key is informed preparation. And, on your way to this high level of preparation, we offer our  free Interview Primers  to spur you along! Download your free copy of  The UVA Darden Interview Primer  today. Share ThisTweet 2019-2020 Business School MBA Essay Analysis University of Virginia (Darden)

Monday, May 25, 2020

Writing a Vietnam War Essay

Vietnam War is a rather ambiguous topic – there is no generally accepted point of view that would explain all its aspects in a manner satisfactory for all the conflicting parties. It has been the reason for a great social upheaval while it was happening, and still it has a lot of potential for analysis using different approaches. As you may see, writing a Vietnam War essay can be, on the one hand, not prohibitively difficult – the information on this topic is readily available to everyone, there are lots and lots of works by celebrated specialists proving this or that point of view, and you can choose any and each one of them without being afraid of not finding anything to support your theory. On the other hand, the memory of it is still very much alive and when writing such a work one has to be considerate enough not to tread on other people’s sore spots. Possible Vietnam War Essay Topics The first step in writing an essay is always choosing a topic; and the right choice may save you a lot of trouble. Generally it is better to make your topic rather neutral – you will have a lot of possibilities to express your point of view in the course of writing, there is no need to shout about it beforehand. Decide what aspect of the war you are going to study, e.g.: Political background and consequences. Strategic aspect. Reasons why the war came to exactly this outcome. Vietnam war essay topics are numerous, you just have to think a little bit and try to choose something not very trite. Relating the History of the Vietnam War Let’s say you’ve decided to write about the history of the war proper, not its geopolitical consequences and suchlike. You may describe the way it went in general, without paying any special attention to specific episodes, but it is most likely a no-win variant, because an essay is a small piece of writing and you won’t have enough time and space to give anything more than a very superficial account of the war. A better approach is to look at the history of the Vietnam War and choose a separate episode, for example, the Tet Offensive, and speak at length about what makes it special, in what ways it influenced the outcome of the war and so on. The narrower the topic is, the better. Hidden Pitfalls of Writing a Vietnam War Paper Vietnam War is a very controversial issue, and different people will have diametrically different opinions about it, including your tutor or professor. Although we don’t suggest that you should try to ingratiate yourself with your tutor and write what he wants to read, it is always a good idea to know who are you writing for. Some people like when students show spirit and are ready to stand up for themselves, some are annoyed by it. Finding out beforehand will make your Vietnam War paper all the more successful.

Thursday, May 14, 2020

The Not-so-Tragic Tragedy of Macbeth Is Macbeth a true...

Amongst all of Shakespeares tragedies, Macbeth is the most inconsistent and fragmented. Like the mental state of the protagonist, the tragic structure of the play is in disarray from the very onset. According to Aristotle, all tragedies must follow a certain set of characteristics, and the most important of these is the presence of a tragic hero. This tragic hero must possess a tragic flaw, or hamartia, which is a good quality taken to such an extreme that it now exhibits immoral behaviour from the hero. He must also draw sympathy of his plight from the audience. Macbeth, although the protagonist, is not a tragic hero because he does not possess this hamartia. This significant absence of a flaw leads to his actions being without†¦show more content†¦Macbeth is self-doubting all through the first three acts of the play; in his lines following the witches initial prophecies, he states Come what come may (I.iii.146), portraying his lack of wilful decisiveness. Yet after the wit ches second set of prophecies, he takes decisive measures to crown [his] thoughts with acts (IV.i.149), and his imagination vanishes. Similarly, Lady Macbeths first statement of Glamis thou art, and Cawdor, and shalt be/What thou art promisd (I.v.15-16) establishes her steely resolve. She is practical and untroubled by any visions. When she realizes the extent of the damage she has caused, however, her imagination takes full reign. In the sleepwalking scene, she is depicted as a broken figure, tormented by imaginative hallucinations. In both cases, imagination comes along when the character is in a disorderly state of mind; therefore, imagination, like ambition, is not Macbeths tragic flaw, testifying that Macbeth does not possess one and therefore is unrecognizable as a tragic hero. Macbeths lack of such a flaw deems all his heinous actions without justification, and as a result, draws no sympathy from the audience. The blame for his lapse in character can be placed upon nothing but his own non-tragic flaws. He is depicted as a cowardly man: he kills Duncan because of his inability to make decisions for himself; Banquo out of paranoia:Show MoreRelatedEssay on Shakespeares Macbeth - The Tragic Hero717 Words   |  3 PagesMacbeth - The Tragic Hero      Ã‚  Ã‚   Every true Elizabethan Tragedy comes complete with a tragic hero.   The tragedy Macbeth, written by William Shakespeare, has a perfect example of a tragic hero, otherwise known as Macbeth.   A tragic hero must be a man who is great and admirable in various ways.   He should be placed in society in such a way that everything he does affects all of the members of his society.   A tragic hero should at some point reach the top of Fortune’s Wheel, but land upRead MoreThe Tragedy Of Macbeth By William Shakespeare1052 Words   |  5 PagesEnglish II 2 October, 2015 â€Å"Tragedy† of Macbeth Macbeth, a play written by one of the most influential English writers of all time William Shakespeare. It was created to be a Shakespearean tragedy. A tragedy as Aristotle defines it as: â€Å"Tragedy, then, is an imitation of an action that is serious, complete, and of a certain magnitude †¦. through pity and fear effecting the proper purgation of these emotions† (Aristotle: Poetics). What this is saying for a tragedy is that it should have the audienceRead MoreDefining a Hero in Shakespeares Macbeth1308 Words   |  5 Pagesdefines a tragic hero, he or she may claim that it is a hero of high class that possesses unprecedented courage and exceedingly strength; thus, a hero who also suffers a calamity of their own downfall and ultimate death through their tragic flaw. Their downfall not only causes infliction on oneself, but also inflicts the society. This can be seen and heavily stressed through William Shakespeare’s tragedy, Macbeth. In his play, the reade r comes across Macbeth, a noble and honorable hero, who ranksRead MoreWhat Are The Similarities Between Macbeth And Othello1267 Words   |  6 PagesWilliam Shakespeare is the playwright in which the works of Macbeth and Othello are written . These works are both written in Shakespeares signature style of tragedy where a character experiences a reversal of fortune at the hands of their own actions. A true tragic hero is a character who is admired while being flawed; has both good and evil characteristics; experiences a hamartia, a moral mistake or ignorant error; is given an opportunity for redemption yet continues refusing; experiences theRead MoreDramatic Literature : The Tragic Hero1607 Words   |  7 PagesThe tragedy is one of the most common forms of dramatic literature in use today. In a general tragedy, the protagonist, known as the tragic hero, is driven towards their inevitable demise by a fault in their personality. This defect in character, or tragic flaw as it is mo st commonly known, leads the tragic hero towards a succession of poor decisions that affects not only the tragic hero, but those around them as well. The tragic flaw can come in a variety of forms, although the most common flawsRead MoreThe Tragedy of Macbeth by William Shakespeare Essay769 Words   |  4 PagesMacbeth is the leading character of Shakespeare’s The Tragedy of Macbeth, in which he struggles to deal with the consequences of his actions. Is he a Tragic Hero? His brutal actions make it very questionable, but yes, Macbeth is a Hero in his own Tragedy. There are positive connotations to being a tragic hero, the first being that in order to be one, the character must have one of the starring roles. It is obvious that Macbeth has a leading part in the play, since not only does it revolve aroundRead MoreMacbeth as a Tragic Hero in William Shakespeares Play Essay935 Words   |  4 PagesMacbeth as a Tragic Hero in William Shakespeares Play The play ‘Macbeth’ by William Shakespeare charts the rise and fall of the Scottish general Macbeth, through a tale of treachery, deceit and death. First performed in 1606 ‘Macbeth’ is inspired by a story of the Scottish monarchy. A tragic hero is one who at the outset is not wholly good or bad but has a character fault that causes them to make tragic mistakes resulting in their eventual downfall. ‘Macbeth’ is a renaissanceRead MoreWilliam Shakespeare s Macbeth Vs. Othello1006 Words   |  5 PagesNadia Chilcoat Macbeth vs. Othello Period: â…š 12/12/2014 Macbeth vs. Othello Ancient Greeks believed that a tragic hero must be admirable but flawed, someone the audience can sympathize with, and someone capable of good and evil. The main character must also have a doctrine of free will, in which they are able to redeem themselves, but they continue to fall freely in a downward spiral from a position of superiority. The audience must also be able toRead MoreMacbeth as a Tragic Hero1513 Words   |  7 PagesMacbeth as a Tragic Hero William Shakespeare s plays have the reputation of being among the greatest in the English language and in Western literature. Shakespeare produced most of his known work between 1589 and 1613. His early plays were mainly comedies and histories, genres he raised to the peak of sophistication and artistry by the end of the 16th century. He then wrote mainly tragedies until about 1608, including Hamlet, King Lear, Othello, and Macbeth, considered some of the finestRead MoreMacbeth: The Tragic Hero Essay1026 Words   |  5 Pages In William Shakespeare’s Macbeth, Macbeth is a classic example of a tragic hero who is constantly struggling with his fate. In the opening scene of the play Macbeth receives a prophecy from three witches. They proclaim that he will be the thane of Cawdor. He responds by saying, â€Å"By Sinel’s death I know that I am thane of Glamis/ but how of Cawdor†(I, iii, 70-73)? At first, he does not realize to earn this title what he must do, but when he realizes he is taken aback. His bewilderment prefigures

Wednesday, May 6, 2020

The Cathedral Of Notre Dame - 888 Words

The Cathedral of Notre-Dame in Reims, northeast of Paris near Champagne was the coronation church of the kings of France and was an educational and cultural center. Also built of limestone, the architecture of the Reims Cathedral features Gothic style. It symbolizes an Early Gothic, Radiant Gothic and Flamboyant Gothic. The Reims Cathedral depicts a classic harmonic facade containing four levels. Its interior is defined by its towering heights and narrow proportions, and elaborate sculptural works. Because of the high quality of workmanship and materials used, Reims Cathedral features some of the most beautiful gothic art in existence. Five different cathedrals have been on the site on which Reims cathedral now sits since 401 CE. The current cathedral was built in 1211, after the previous cathedral had burned down. The new building was almost entirely finished by the end of the thirteenth century. 88 gargoyles were counted on the Reims Cathedral and are mainly used to drain of f rainwater and are exceptional pieces of work, but do show the slight difference between Gothic and Romanesque styles. The stained glass windows are a beautiful part of Reims despite being damaged or ruined several times in the 18th century; the cathedral still has many 13th century stained glass windows, in the upper parts of the nave, choir and transept. On the opposite side of the great western portal, the Great Rose Window, dating from the end of the 13th century, represents â€Å"the CrowningShow MoreRelatedAnalysis Of Notre Dame Cathedral1022 Words   |  5 PagesIntroduction Notre-Dame Cathedral on the  Ile de la Cite  in  Paris is one of the most recognised Gothic structures of medieval Europe. It is considered a fine example of new architectural strategies of the twelfth century, as well as a symbol of socio-political power of the Catholic Church within this period (Swaan, 1988). Therefore, the cathedrals design and construction highlight advances in art and building strategies throughout the history of European culture. This essay is going to discuss Notre-DameRead MoreA Visit to the Notre Dame Cathedral586 Words   |  2 PagesThe Notre Dame Cathedral is certainly one of the most beautiful locations in the world, as the city of Paris as a whole and the buildings surroundings contribute to making visitors acknowledge the importance of this monument. Construction on the cathedral started in 1163 and was largely finished by 1250, with most of its features emphasizing Gothic influences. The buildings architecture, the sculptures present in it, and the impressive stained glass all stand as reminders that the French communityRead MoreAnalysis : The Hunchback Of Notre Dame816 Words   |  4 PagesHunchback of Notre Dame, pages 85-165 Victor Hugo finishes the background and introduction of the characters and begins the plot by setting up the antagonist. During these pages, Hugo continues to allude to many different historical figures and events, provides vivid descriptions of the Notre Dame cathedral and makes it an important symbol in the book. In The Hunchback of Notre Dame, Hugo gives the reader the first look at the Notre Dame cathedral. Hugo personifies the cathedral by using the wordsRead MoreGothic Cathedrals, Compare and Contrast Two846 Words   |  4 PagesGothic Cathedrals The Gothic style has been the root for some of mankind’s most beautiful works of art. It was introduced by the Romanesque style of building. Romanesque style only lasted for nearly one hundred years before the Gothic style replaced it entirely. Abbot Suger was the founder of the Gothic style. One great form of Gothic architecture was the Notre Dame de Chartres cathedral that was built in France between 1145 and 1513. Another form is the Bourges cathedral, located in BourgesRead MoreComparison and Contrast of Two Gothic Cathedrals Essay625 Words   |  3 PagesComparison and Contrast of Two Gothic Cathedrals Gothic Style is some of the most beautiful works of art that man have ever made. It originated with the Romanesque style of building which lasted for about one hundred years before it was replaced by Gothic styles. The founder of the Gothic style was a man by the name of Abbot Suger. Notre Dame de Chartres cathedral was built in France between 1145 and 1513 and is Gothic architecture. Another Gothic architecture is the Bourges and it isRead MoreThe Sad Theme of the Hunchback of Notre Dame806 Words   |  3 Pages Is always a happy ending? The Hunchback of Notre Dame is a book by Victor Hugo written in 1831. Victor Hugo was born in Besancon, France on February 26, 1802. The Hunchback of Notre Dame is a French Romantic/Gothic genre book. Hunchback of Notre Dame involves around Quasimodo a hunchback. The Hunchback of Notre Dame has many different themes. I believe one of the biggest theme is you shouldnt judge based on appearances. The Hunchback of Notre Dame is a very sad book, but with it being sad thereRead More Saint Sernin Of Toulouse And Notre Dame Of Paris Essay701 Words   |  3 PagesSaint Sernin of Toulouse and Notre Dame of Paris   Ã‚  Ã‚  Ã‚  Ã‚  When one thinks of St. Sernin and Notre Dame, one tends to think of two beautiful cathedrals, not to churches that portray two totally different styles of architecture. Those two styles are, of course, Romanesque in St. Sernin and the Gothic style of Notre Dame. Some characteristics that these two buildings share include quest for height, basic floor plan, and artistic flair. The period of Romanesque architecture, which lasted roughlyRead MoreNotre Dame Of Chartres And The Temple Of Khonsu1703 Words   |  7 Pages Gloria Morales HUMN 241 Prof. Ho 11/18/2015 Paired Places: Written Assignment Notre Dame of Chartres and the Temple of Khonsu By studying the design of the Norte dame of Chartres cathedral, in France and the Temple of Khonsu located in Egypt. We can emphasize how both buildings relate with each other. The Chartres cathedral and the temple of Khonsu have numerous of connections with other. 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Tuesday, May 5, 2020

The Pathogenesis of Brian Colorectal Cancer

Question: Describe the pathogenesis of Brians colorectal cancer from the initial cellular mutation to the diagnosis of stage IIA colorectal cancer? Answer: In the case of colorectal cancer, discussing about the pathogenesis of colorectal cancer mutations in KRAS is defined as an initial event in the term of pathogenesis. It has been reported that mutation in KRAS demonstrated in 50% of adenomas and hence defined as a key genetic modification that is useful to the development of adenoma to colorectal cancer. It has been found that progression of KRAS mutation is a vital stage in the multistep phenomenon in cancer development. Mutation in KRAS is been associated with very fast and competitive metastatic action of liver metastases. It has been found that there are several liver metastases that were associated with the high expression of KI67 and KRAS have shorter time lapse to be detected as it has restriction with colon and poor survival. Mutation KRAS is associated with C12V is associated to hepatic metastasis along with several lung and colon metastasis. For the treatment module role of KRAS is very critical as it is associated with the deprived response rates of several therapeutic agents thus the mutational role of KRAS act as a deciding step in validating therapies for colorectal cancers. KRAS is associated with epidermal growth factor receptor (EGFR) which is a tyrosine kinase and present on maximum colorectal tumours as it is known to KRAS decrease the response of agents which are anti EGFR. Mutation in KRAS and their implementation in cancer biology have been validated for past decade. KRAS has second highest prevalence of colorectal cancer and this therapy may be well validated in coming durations and at present act has promising approach (Cong and Xiang, 2012) Describe two (2) modifiable and three (3) non- modifiable risk factors for colorectal cancer and explain how these risk factors may have contributed to the development of Brians colorectal cancer. There have been several evidences that denotes about several factors including several dietary and lifestyle factors that influences the risk of colorectal cancer. Physical inertness, overweight and a deposition of adiposity are consistent risk factors as these parameters serves as major contributors to the high rates of colorectal cancer in several nations. In the recent advancements study indicates the chronic hyperinsulinemia as a major risk factor as it increases the risk of colon cancer because insulin resistance and hyperinsulinemia is promotes by over intake energy and in terms of the Western food routine and culture (e.g., saturated fats and refined carbohydrates), it may be a termed of factors that increses the colorectal cancer. Over consumption of liquor in combination with diet possessing deficit in micronutrients like methionine and folate and smoking likely to increases risk of colorectal cancer especially folate is a nutrient that has been well explores and bears in ra ndomized clinical trials (Giovannucci, 2002). Some of the other risk includes age, personal history of polyps and inflammatory bowel disease, possessing some kind of syndromes, ethnic background and diabetes. Person having past history of adenomatous polyps (adenomas) are at the high risk of colorectal cancer. In inflammatory bowel disease including Crohn's disease and ulcerative colitis where colon stays inflamed for long duration, if untreated turns to dysplasia where it possess growth of cells at lining of colon which in case of uncontrolled management turns to colorectal cancer. Individual having family history of adenomatous polyps or colorectal cancer are at high risk to be having colorectal cancers. Mutation in several genes may result in development of colorectal cancer like mutation in APC gene causes in Familial adenomatous polyposis (FAP) and defect in MLH1 or MSH2 gene leads to Hereditary non-polyposis colon cancer (HNPCC) (Al-Sukhni et al., 2008). A recent study reveals that mutations in the gene MUTYH causes MUTYH-associated polyposis (Schlussel et al, 2014) Describe the action and mechanism of action of metronidazole (Flagyl) in relation to its administration to Brian. Describe the action and mechanism of action of morphine in relation to its administration to Brian. Metronidazole is the major component which is found in plasma along with 2-hydroxymethyl metabolites and circulating metronidazole is bound to plasma proteins. Metronidazole is the productive antianaerobic drug validated in an in-vitro condition. An extensive and wide clinical trial to analyse metronidazole along with neomycin towards erythromycin and neomycin as bowel composition showsd a remarkable reduction in anaerobic flora in individual bearing metronidazole (Hinchey et al, 1983). Morphine is developed as god standard for the pain relieve as it is one of the best drug available for the better pain management and it is clinically very effective in cancer pain. Morphine acts on the central nervous system directly for relieve in pain by activating the peripheral tissues as well as it help in migration and proliferation of tumour cells. morphine is found very important for the maintenance of neoplastic tissues (Gach et al, 2011) . Discuss the nursing responsibilities with associated rationales in relation to administering Morphine to Brian. For nursing care it requires multidisciplinary approach towards patient care to meet the expected care Etiology Though the exact reason behind the development of colon cancer is unknown but still several risk factors have been identified that progresses after the age of 40 in both male and females. Ranging from formation of multiple adenomatous polyps to development of colorectal cancer extensive nursing care is involved Diagnosis While diagnosis it nursing personnel should always remember that there is no outward symptom to identify the disease so minute observation for the initial symptom should be taken with deep concern. Abdomen pain, tarry stools, anaemia, intestinal obstruction and unexplained reduction in weight must be considered at initial examination. Proper radiological examination of abdomen must be done along with colonoscopy and faecal occult blood test must be done and if diagnosis is positive then barium enema and flexible sigmoidoscopy should be done for further follow ups. Treatment Primary treatment for the colorectal cancer is colon surgery but the choice of surgery depends upon the tumour location and organ involved. Post-operative care which involves radiotherapy and chemotherapy must be done in proper nursing care. Teaching Nursing staff should be enough efficient to teach the patients the positive and negative impact of the disease along with proper care. Drug management, pain management and timely maintenance of patient surrounding should be done to avoid post-operative complications. Discharge planning Nurses should instruct the patient about post-operative complication like erythema, chills, wound separation, fever, shortness of breath, and more and advised to visit as soon the complication appears again (Toth, 2006). References Giovannucci E. 2002. Modifiable risk factors for colon cancer. Gastroenterol Clin North Am.31(4):925-43. Haggar FA and Boushey RP. 2009. Colorectal Cancer Epidemiology: Incidence, Mortality, Survival, and Risk Factors. Clin Colon Rectal Surg. 22(4): 191197. Cong Tan, Xiang Du. 2012. KRAS mutation testing in metastatic colorectal cancer. World J Gastroenterol.18(37): 51715180 Gach K, WyrÄâ„ ¢bska A, Fichna J, Janecka A. 2011. The role of morphine in regulation of cancer cell growth. Naunyn Schmiedebergs Arch Pharmacol. 384(3): 221230. Hinchey EJ, Richards GK, Prentis J. 1983. Metronidazole as a prophylactic agent in wound infection after colon surgery. Surgery. 93(1-2):197-200. Toth PE. 2006. Ostomy care and rehabilitation in colorectal cancer. Semin Oncol Nurs. 22(3):174-177. Schlussel AT, Gagliano RA Jr, Seto-Donlon S, Eggerding F, Donlon T, Berenberg J, Lynch HT. 2014. The evolution of colorectal cancer genetics-Part 2: clinical implications and applications. J Gastrointest Oncol. 5(5):336-44. Al-Sukhni W, Aronson M, Gallinger S. 2008. Hereditary colorectal cancer syndromes: familial adenomatous polyposis and lynch syndrome. Surg Clin North Am. 88(4):819-844